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Periactin (CYPROHEPTADINE) is a piperidine antihistamine. Unlike other antihistamines, this drug also antagonizes serotonin receptors. This action makes Cyproheptadine useful in conditions such as vascular headache and anorexia. Cyproheptadine does not prevent the release of histamine but rather competes with free histamine for binding at HA-receptor sites. Cyproheptadine competitively antagonizes the effects of histamine on HA-receptors in the GI tract, uterus, large blood vessels, and bronchial smooth muscle. Most antihistamines possess significant anticholinergic properties, but Cyproheptadine exerts only weak anticholinergic actions. Blockade of central muscarinic receptors appears to account for Cyproheptadine's antiemetic effects, although the exact mechanism is unknown. Cyproheptadine also competes with serotonin at receptor sites in smooth muscle in the intestines and other locations. Antagonism of serotonin on the appetite center of the hypothalamus may account for Cyproheptadine's ability to stimulate appetite. Cyproheptadine also has been used to counter vascular headaches, which many believe are caused by changes in serotonin activity, however it is unclear how Cyproheptadine exerts a beneficial effect on this condition. For treatment of perennial and seasonal allergic rhinitis, vasomotor rhinitis, allergic conjunctivitis due to inhalant allergens and foods, mild uncomplicated allergic skin manifestations of urticaria and angioedema, amelioration of allergic reactions to blood or plasma, cold urticaria, dermatographism, and as therapy for anaphylactic reactions adjunctive to epinephrine.
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п»їWhat should I discuss with my healthcare provider before taking Periactin (cyproheptadine)?
You should not use this medication if you are allergic to cyproheptadine, or if you have:
narrow-angle glaucoma;
a stomach ulcer or obstruction;
an enlarged prostate or urination problems;
if you are having an asthma attack;
if you are elderly or have a debilitating disease.
If you have any of these other conditions, you may need a dose adjustment or special tests to safely use this medication:
glaucoma;
a history of asthma;
high blood pressure;
heart disease; or
an overactive thyroid.
FDA pregnancy category B. Cyproheptadine is not expected to be harmful to an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant during treatment. It is not known whether cyproheptadine passes into breast milk, but if it does it could harm a nursing baby. Do not use this medication while you are breast-feeding a baby. Do not give this medication to a child younger than 2 years old. Older adults may be more likely to have side effects from this medication
More Periactin resources
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Cyproheptadine
Compare Periactin with other medications for the treatment of:
Hay Fever, Migraine, Cluster Headaches, Pruritus, Allergic Reactions, Anorexia, Anorexia Nervosa, Sexual Dysfunction, SSRI Induced, Cushing's Syndrome, Urticaria
User reviews
5 review(s) for Periactin
Support Group Questions & Answers
Periactin - do they normally prescribe to children under18 who have migranes and absent siezures?
If I did a drug test while taking this will I fail it periactin?
Can periactin increase your appetite?
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